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TRAF6-mediated SM22 K21 ubiquitination promotes G6PD activation and NADPH production, contributing to GSH homeostasis and VSMC survival in vitro and in vivo

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At 68 weeks, average body weight loss was 16.6% (95% CI -17.1 to -16.0)

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doi: 10.1016/S0344-0338(96)80034-3 7 LudvkovMMichalMMarekJSyrucekM

Its metabolic journey is a prime example of tissue-specific post-translational processing, where the same precursor is cleaved into different bioactive peptides depending on the enzymes present in the cell [27] [Figure 2]