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GLP-1 is a key gut-derived hormone that plays a crucial role in satiety signaling, which were synthesized both in enteroendocrine L cells and neurons in NTS [42]
Heerspink , PhD, professor of clinical trials and personalized medicine and a clinical pharmacologist/trialist in the department of clinical pharmacy and pharmacology at the University Medical Center Groningen in the Netherlands, told Healio
While GLP-1R-decorated nanocarriers can effectively bind and internalize into target cells, quantitative imaging studies indicate that less than 2% of the internalized nucleic acid payload escapes from endosomal compartments into the cytosol
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