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Supplementary Information 40104_2025_1351_MOESM2_ESM.docx (download DOCX Additional file 2: Table S1
In humans, GH secretion during early sleep may be nearly totally suppressed by administration of a specific GHRH antagonist ( Growth hormone injections are traditionally timed to align with the natural circadian rhythms of GH secretion, typically during the early night, to coincide with the onset of slow-wave sleep ( We hypothesized that daily GH injections given in the evening could disrupt sleep both by inhibiting GHRH secretion, and due to the discomfort and psychological distress associated with the injection and local reactions
Instead of teaching the patient/a family member to self treat they decided to just cut the injection frequency and to hell with the consequences
Presented for research literature review only Jkw P et al
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