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doi:10.1056/NEJMoa2301972 PubMed: This landmark study demonstrated 24.2% mean weight loss at 48 weeks with the 12mg dose in 338 adults with obesity, establishing retatrutide as the most effective obesity medication tested to date

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Editorial Note: This article was reviewed by the research team at Omni Peptides and is based on publicly available clinical trial data and peer-reviewed research available as of June 2026

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