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Hair thinning has been noted in association with retatrutide, likely related to rapid weight loss triggering telogen effluvium, though a direct pharmacological effect cannot be excluded as alopecia is listed as an adverse reaction with some licensed GLP-1 receptor agonists
The decision to discontinue semaglutide should be made through shared decision-making with your healthcare provider who can assess your individual circumstances and develop an appropriate plan
Patients should seek urgent medical attention if they cannot keep fluids down for more than 24 hours, experience reduced urine output, or feel dizzy when standing
With insulin, there is risk of weight gain, for hypoglycemia, and theres more treatment burden and need for glucose monitoring. GLP-1 drugs have also been shown to have cardiovascular benefits, she adds, though further clinical trials are needed to assess orforgliprons effects on heart health
Changes are typically small, often a 25 microgram change
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