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The calculator first determines the concentration of the solution

Women who were pregnant, lactating, or had not adhered to adequate contraception from at least 30 days prior to the study entry and did not plan to for 1 month after the final supplementation were also excluded

Additionally, CoQ10 itself acts as a potent lipid-soluble antioxidant, providing a second layer of defense against lipid peroxidation within the mitochondrial membrane