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Eli Lillys Phase 3 TRIUMPH-4 trial (December 2025) reported that participants taking 12mg of Retatrutide over 68 weeks lost an average of 28.7% of their body weight, the highest result ever reported at that stage for any obesity-related compound
However, a randomized controlled trial by Berro et al
Basotti G, et al
SURMOUNT-1 Trial
Marsico F, Paolillo S, Gargiulo P, Bruzzese D, DellAversana S, Esposito I, Renga F, Esposito L, Marciano C, Dellegrottaglie S, Iesu I, Perrone Filardi P
Eating disorders and the language around them were rampant and the predominant aesthetic was that of the sad girl (think Arctic Monkeys AM album, sweaters pulled down to the shoulders to expose the protruding collarbone, black-and-white images from Polaroid cameras, and Dr
