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ChaC1 overexpression can augment apoptosis by activating caspase-3/9, degradation of poly (ADP ribose) polymerase, induction of autophagy, ROS generation, increased intracellular calcium and loss of mitochondrial membrane potential (69)
Its role in energy metabolism can combat fatigue and improve exercise performance by enhancing muscle function and reducing muscle damage during workouts
Two observational studies have reported that there is an increased urinary excretion of 3-HIA during pregnancy, though other indices of biotin status were not consistently altered (23, 24)
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