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While it is not "mandatory" in the sense that the supplements won't work without it, Vitamin C is highly recommended as a co-factor

Next, we clean the injection site, typically the thigh, upper arm, or abdomen, with an alcohol wipe and allow it to dry completely to minimize irritation

2000 Jul;38(7):625-34 No Abstract [3] Kidd PM

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Increased Heart Rate (Tachycardia) Albuterol can cause your heart to beat faster, a condition known as tachycardia

Both scenarios are valid depending on the underlying health context