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Lighter individuals may achieve good results at lower doses (300-350mcg)

While the assumption of no intercurrent events is often not entirely realistic, this estimate is the closest we can currently get to an estimate of the true pharmacological effect of the drug and is referred to as the trial product estimate

At the beginning of pregnancy, low vitamin B12 levels can increase the risk of neural tube defects

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The synergy between the two receptor pathways is present even at low doses, which is an argument for tirzepatide-based microdosing over semaglutide-based microdosing from a metabolic standpoint