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This is because issues with regular function of the gastrointestinal tract can prevent the proper release and absorption of the vitamin, which can cause a deficiency if not supplemented properly

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While some folks might notice changes in their appetite and weight early on, the most significant weight loss usually happens over the first four to five months

2.2 In silico multiscale modeling framework The in silico multiscale modeling framework used to showcase dose-dependent variability consists of three major components (as shown in Figure 1)