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Animal experiments have not shown significant adverse effects at therapeutic dosages

"Effects of vitamin B12, on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cells"

, Oral, transdermal and vaginal combined contraceptives induce an increase in markers of chronic inflammation and impair insulin sensitivity in young healthy normal-weight women: a randomized study, Human Reproduction , vol

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At this concentration, a 0.25mg dose equals about 7.5 units on a U-100 insulin syringe