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In doing so, they generate reactive oxygen species (ROS) as a by-product ( 8 PD and mitophagy Mitophagy, also known as mitochondrial autophagy, is a type of autophagy, a self-regulatory process used by cells to degrade ectopic and/or aggregated proteins and impaired organelles ( In the MPP + -induced PD model, Sirts were found to be degraded primarily through autophagy rather than the proteasome ( 2 O 2 or its decomposed products, oxidizes Sirts, which co-localise with autophagosomal structures and are degraded via autophagy
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