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Dehydration and electrolyte imbalances (particularly sodium, calcium, or magnesium) resulting from gastrointestinal side effects could theoretically affect nerve function, though this is less commonly reported

It may also help anemia due to folate deficiency, which is common among pregnant and postpartum women

Managing side effects during titration Gastrointestinal side effects are the most common barrier to successful tirzepatide use

I hope Adele, and the media, remember that

#NAMs #Toxicology #DrugDiscovery #3DCellCulture #InSphero #NewApproachMethodologies #PreclinicalTesting #RegulatoryScience To view or add a comment, sign in Reducing Animal Use in Intravitreal Biologics A recent study highlights practical ways to reduce animal use in developing intravitreal therapies

Pharmacokinetic Uncertainties Smaller doses may behave differently than expected: Absorption variability: Smaller volumes may have different kinetics Injection site effects: Multiple sites per week increase variability Threshold effects: Minimum concentration needed for efficacy unknown Receptor occupancy: May need sustained levels for full effect 4