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Jay looked at an $850 billion to $1 trillion prescription drug market growing at roughly 10% a year and thought: this is medieval
However, due to receptor-level adaptations and downstream neuroplastic changes, clinical efficacy typically requires 46 weeks of continuous administration
A 150-pound and a 250-pound patient typically use similar doses because the mechanism is signaling-based rather than concentration-based
Even if GLP-1s reduce downstream costs by preventing dialysis, cardiovascular events, or hospitalisations, insurers may still apply stage-based restrictions, mandate prior use of increasingly generic SGLT2i use, or limit treatment duration
Credit to Dr
So we gotta be checking those levels
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