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Shifts gene expression toward younger Using the Broad Institute's Connectivity Map, researchers found GHK-Cu modulates over 4,000 human genes, moving expression away from aged, damage-prone patterns and toward regenerative ones
Study Design: Randomized controlled trials and observational cohort studies were included
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The apparently higher frequency of dose reductions in the subgroup with delayed escalation may reflect selection biasclinicians may have advanced escalation more cautiously in patients perceived to be at higher risk for gastrointestinal intoleranceas well as ascertainment bias or unmeasured confounding, rather than a direct causal effect of delayed escalation per se
