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Eur J Prev Cardiol 31:12601273 Hankosky ER, Wang H, Neff LM et al (2024) Tirzepatide reduces the predicted risk of atherosclerotic cardiovascular disease and improves cardiometabolic risk factors in adults with obesity or overweight: SURMOUNT-1 post hoc analysis

The formulation appears to support metabolic function and energy production, which has been helpful in maintaining consistency with diet and activity levels

The evidence base for use of these drugs, either for off-label indications or as non-approved drugs, is wanting

Identification of inhibitors of protein-protein interactions has been a major challenge in drug discovery, yet screening strategies, including high-throughput screening and fragment-based drug design, are able to identify compounds suitable for drug development

As of writing, retatrutide is still in Phase 3 trials