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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome

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Experimental observations and model development We developed a mechanistic model focused on the regulation of intracellular lipolysis and the release of fatty acids and glycerol from the adipose tissue

Individuals considering extended protocols should discuss this temporal limitation with healthcare providers and maintain appropriate monitoring throughout treatment