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Among these, Glp1r-expressing neurons in the hindbrain, particularly in the dorsal vagal complex composed of AP and NTS, have been identified as critical mediators of GLP1RA effects, providing key insights into the neural circuits underlying obesity therapeutics 15

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Typical side effects include nausea, vomiting, diarrhea, and constipation, which are generally mild and tend to diminish after a few weeks of treatment

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