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This matters when you are drawing multiple doses from a single vial over the course of several weeks

Other biochemical factors work against you, making it hard to lose weight or keep it off

In the LOOK AHEAD trial (N=5,145), intensive lifestyle intervention producing 8.6% weight loss at year 1 was associated with significantly less kidney function decline over 4 years compared to usual care (JASN 2014, Gregg et al.)