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These biomarker changes can be read out well before clinical symptoms become evident, allowing for timely intervention to adjust or discontinue treatment

This was done intentionally to avoid issues of applying a single standard cutoff value across various populations and communities

Vasorelaxation at least 60% by 3 M ACh in rings pre-contracted with 3 M PE was considered endothelium intact

CrossRef Supplemental hydroxychloroquine therapy regulates adipokines in patients with systemic lupus erythematosus with stable disease Risa Wakiya, Kiyo Ueeda, Hiromi Shimada, Shusaku Nakashima, Tomohiro Kameda, Nobuyuki Miyatake, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Mao Mizusaki, Rina Mino, Norimitsu Kadowaki, Hiroaki Dobashi Clinical Rheumatology.2022

The extent to which DMA(V) can be reduced to the more toxic DMA(III) is unclear although there is some evidence that DMA(III) is also found in human biologic samples (Valenzuela et al

DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, O'Keefe JH