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doi: 10.3389/fphar.2025.1669951 Received 20 July 2025 Accepted 19 September 2025 Published 03 October 2025 Volume 16 - 2025 Edited by Yang Zhou, Brown University, United States Reviewed by Hanlin Yin, Shanghai Jiao Tong University, China Anna Maria Giudetti, University of Salento, Italy Updates Copyright 2025 Misztal, Kaniewska-Kosiska, Woyniak, Maecka-Wojciesko and Fabisiak

Autocrine GH for instance, is thought to be more oncogenic than pituitary GH, and the autocrine/paracrine IGF1 is the main determinant of postnatal body growth, including muscle and bone tissue development, confirming the conclusion that pituitary GH and circulating IGF1 are critical for body size and affect numerous body functions, for these body functions, local GH and IGF1 may be more relevant

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When researchers isolated and studied it, they discovered something remarkable: exogenous BPC-157 (injected or supplemented) dramatically accelerates the repair process far beyond what your natural levels alone can achieve

Combined senolytic + mitochondrial approaches are an area of active longevity research interest.

& Ranganath, L