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Standard FDA-approved escalation The protocol moves in 2.5 mg increments, each held for at least four weeks: Weeks 1 to 4: 2.5 mg once weekly (initiation dose, not therapeutic) Weeks 5 to 8: 5 mg once weekly (first therapeutic dose) Weeks 9 to 12: 7.5 mg once weekly Weeks 13 to 16: 10 mg once weekly Weeks 17 to 20: 12.5 mg once weekly Week 21 onward: 15 mg once weekly (maximum dose) Not everyone reaches 15 mg

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