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If it has not, I think harder about dose, about the route of administration (oral versus intramuscular), and about other possible contributors
you need to get it from food or oral supplements
I started B 12 injections 3 monthly after the loading injections and it helped a little but the fatigue didnt clear as quickly as my doctor expected
Other serious consequences: your anemia can get so severe it causes heart failure and collapse
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To sum up, some patients report the worsening of symptoms within the first few days or weeks when they begin B12 shots
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