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Subsequent reporting in The BMJ noted that a second generic version from the Canadian company Apotex was also approved by Health Canada in the weeks that followed, and that seven other applications remained under review at the time of publication
Yet, from a formulation and manufacturing perspective, these APIs still come with the classic limitation of peptide drugs: they are fragile, easily degraded, and difficult to deliver through the gastrointestinal tract
Compounded semaglutide from an FDA-registered 503A or 503B compounding pharmacy represents a legal, prescription-required alternative that was widely available during the Ozempic and Wegovy shortage periods
Kipnis adds
However, the timing of discontinuation matters because of the long half-life
The available data from extended clinical trials suggests that tirzepatide continues to exert its therapeutic effects on glucose control and weight management without requiring dose escalation beyond the standard titration schedule
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