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Rarely, patients may experience hypersensitivity reactions to cobalt or vitamin B12, including rash, itching, acneiform eruptions, or in exceptional cases, anaphylaxis

PMID 2249981

For aggressive muscle-building protocols, some do morning + pre-workout + bedtime (this should only be done under medical supervision)

Injury Severity Dosing Data for BPC-157 BPC-157: Take It Once Daily or Split - The Half-Life Question The sub-30-minute plasma half-life documented in He et al