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Combined Approaches (Neelakantan et al., 2022): NNMT inhibition with reduced-calorie diet produced dramatic adiposity reduction in DIO mice, normalizing metabolic parameters and establishing a distinct gut microbiome

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Furthermore, the hormonal changes associated with significant weight fluctuations may temporarily affect menstrual regularity and ovulation, though this typically normalises after medication cessation

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Most constipation appears during the first 2-4 weeks as your body adapts, but some patients experience ongoing mild symptoms