Things like aging, certain health conditions, or even some medications can make it difficult for your body to use the B12 from your food
2000 in Hormone Research showed that 21-day oral AOD-9604 (500 mcg/kg/day) reduced body weight gain by roughly 50% in obese Zucker rats with no insulin sensitivity penalty
M., Sun, J., Sharma, L., Libinaka, R., Jiang, W
The GLP-1 fatigue guide covers this phenomenon in detail
Although results may not be instant, improvements can be observed within a relatively short period
[2] Since then, several other GLP-1 agonists have been developed and approved for clinical use, including liraglutide (Victoza), dulaglutide (Trulicity), semaglutide (Ozempic and Wegovy), and Tirzepatide (Mounjaro and Zepbound)