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The epigenetic regulation includes DNA methylation, posttranslational histone protein modifications such as acetylation, methylation, and phosphorylation, and microRNAs (noncoding RNA) that can inhibit translation or degrade mRNAs by modulating gene expression (Dehan et al., 2009)

We suggest the following IV dosing plan: Rate of Administration Guidelines The speed of IV administration is important to avoid bad effects

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This minimizes the risk of receptor down-regulation and allows the somatotrophs to replenish their hormone stores before the next pulse occurs

JAMA 281(15):14151423 Litovitz TL, Klein-Schwartz W, Caravati EM, Youniss J, Crouch B, Lee S (1999) 1998 annual report of the American Association of Poison Control Centers toxic exposure surveillance system

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