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Semax is a synthetic heptapeptide analog of ACTH(4-10) with the natural Arg-Trp-Gly C-terminal replaced by Pro-Gly-Pro

Le-Le L, Han Yu, Zi-Jia Z et al (2023) Loss of DJ-1 function contributes to Parkinsons disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation

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For clinical deficiency loading, weekly injections for four to eight weeks are typical, followed by monthly maintenance