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a Senior Research Fellow of the NHMRC
And with weight gain comes the return of insulin resistance. If you discontinue the medication, lifestyle interventions can partially preserve insulin sensitivity improvements after you stop taking the meds, says Silvana Obici, MD, the chief of the division of endocrinology at Stony Brook Medicine and the medical director of the Stony Brook University Hospital Diabetes Center in New York
It takes time to run medical studies
The medication doesn't specifically "make you poop" in the sense of acting as a laxative, but rather modifies your overall digestive transit and function
A slower pace reduces physiologic shock and makes nutrition easier to manage while you remain on tirzepatide
Microbial contamination becomes a concern if a vial has been opened beyond the recommended 28-day window or stored improperly
