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GLP-1 receptor agonists (like semaglutide/Ozempic) and dual GLP-1/GIP agonists (like tirzepatide/Mounjaro) were originally developed to treat type 2 diabetes

doi:10.1016/j.eclinm.2025.103464 Available from: 11

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For peripheral tissues such as liver and pancreas, it is difficult to identify reference tissues (which should exhibit similar perfusion and tracer delivery, but without receptor expression)

[2] [9] However, other research suggests that the proportion of people with low or marginal levels of vitamin B 12 is up to 40% in the Western world