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In addition, RNF4 mediates the proteasomal clearance of SUMOylated post-replicative DNA protein crosslinks (DPCs), including TOP1/2- and DNMT1-DPCs which are induced by topoisomerase poisons or hypomethylating agents 20,28,29

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Common side effects include gastrointestinal symptoms (nausea, vomiting, diarrhoea)

Scholz H, Heimendahl EV, Menn F, Ahrens A