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(2018) found that sertraline causes impaired the steroidogenesis of sex hormones in male rats through the direct inhibition of steroid synthesis and its indirect effects on gene expression, and plasma LH levels and LH/testosterone ratios were significantly increased, potentially triggering compensatory hypogonadism

Correlation between psychiatric disorders and metabolic disorders such as obesity In summation, according to the Nature paper, people are experiencing psychiatric side effects from prolonged GLP-1 use

10.1056/NEJMoa1607141 14 McIntyreR

Adverse drug effects can be due to direct toxicity, for instance as a result of kidney-specific determinants, or indirectly by, e.g., vascular effects or crystals deposition