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11 GSH depletion and the subsequent low stores of protein thiol result in both calcium release from intracellular stores and inhibition of calcium extrusion, producing a marked increase in cytosolic calcium concentration, which triggers cytotoxicity

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Yet, building capacity has proven to be a multi-year endeavor a fact underscored by continuing shortages and regulatory interventions ( [12] ) ( [60] )

Reported does not mean recommended PDP includes the 16-week figure because it appears in KLOW research discussions