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Notably, significant abnormalities are observed in pathways such as galactose metabolism, steroid biosynthesis, and bile acid biosynthesis. Post-treatment with metformin, MAFLD rats demonstrated notable changes in certain metabolic pathways, particularly in PPAR signaling and fat digestion and absorption. This suggests that metformin may regulate these specific metabolic pathways, aiding in restoring normal metabolic functions or at least alleviating metabolic dysregulation
However, these studies found no significant improvements in a range of safety endpoints for cardiovascular diseases ( The Role of DPP-4 Inhibitors in Hypertension The first DPP-4 inhibitor, sitagliptin, was approved as an anti-hyperglycemic agent for T2DM in the United States of America in 2006
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