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By far, the most commonly reported side effects of using semaglutide are gastrointestinal upsets - nausea, vomiting, diarrhea, constipation, heartburn, and stomach pain

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The addition of GCGR agonism to GLP-1R agonism may therefore prove to be more efficacious in the treatment of type 2 diabetes and obesity, producing additive effects on energy intake and expenditure

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Mastrandrea LD, Witten L, Carlsson Petri KC, Hale PM, Hedman HK, Riesenberg RA