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It inhibits acetaldehyde dehydrogenase, causing a five-to ten-fold increase in the concentration of acetaldehyde in the body after drinking alcohol, as happens spontaneously in people subject to flush

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Gonadotrophic control of human granulosa cell glycolysis

While most of the actions of metformin appear to be mediated by cellular activation of AMP-activated protein kinase (AMPK), their findings indicate that the effects on incretin receptor expression in beta cells appear to be independent of AMPK, but, rather, are mediated by peroxisome proliferator-activated receptor (PPAR), as metformin failed to induce expression of the gene encoding the incretin receptor in islets from Ppar knockout mice [10]

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