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According to ProHealth's published materials and published nutritional science, butyrate is described as playing roles in supporting the intestinal environment, promoting a balanced microbiome, regulating colonic pH, and contributing to gut-brain communication pathways - mechanisms supported by nutritional research at the ingredient level

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For FRAA-positive participants, improvement in verbal communication was significantly greater in those receiving folinic acid as compared with those receiving placebo, resulting in an effect of 7.3 (1.4,13.2) standardized points with a large effect size (Cohens d =0.91), indicating that folinic acid treatment may be more efficacious in children with ASD who are FRAA positive