how long do i have to take semaglutide Does Work? Results Timeline How Long Can You Take

Approved long-term agents, orlistat, phentermine/topiramate, naltrexone/bupropion, liraglutide, semaglutide, and tirzepatide, differ in mechanism, weight-loss magnitude, and safety considerations

Weekly or twice-weekly dosing (depending on the formulation) also means fewer daily decisions compared to daily pills

Weeks 2-4: IGF-1 Accumulation Phase This is where the biochemistry shifts from acute GH pulses to sustained IGF-1 elevation

Johnson KC et al

Acknowledgements The authors declare financial support was received for the research, authorship, and/or publication of this article

Taken together, these results may suggest that GLP-1 is an important mediator of the stress response in the brain