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GLP-1 medications activate receptors in your brain and digestive tract that signal fullness, reduce hunger, and slow gastric emptyingchanges that fundamentally alter how foods feel in your stomach and how much you can comfortably consume

Binding specificity and signal transduction of receptors for glucagon-like peptide-1(7-36)amide and gastric inhibitory polypeptide on RINm5F insulinoma cells

There is no "safe window" where the medication is inactive

Expectations are always high at the start of treatment, so when disappointment and discouragement are piled on top of depression, the next step can be despair