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DOI: 10.1021/jm9801962 Johansen PB, Hansen KT, Andersen JV, Johansen NL
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Some branded GLP-1 medications continue to be in short supply and patients often face drug shortages along with high costs that currently limit access to the branded medications
Even though they target the same hormone, the two peptides behave differently in the body and produce distinct effects
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Pairing them in one pen exploits non-overlapping desensitisation pathways: GHRH-R signals through Gs/cAMP while GHS-R1a couples Gq/PLC, so receptor downregulation on one axis does not blunt the other during repeat-dose research models
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