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16,17 Whether GLP-1 RAs protect against lithium-induced nephrotoxicity is unknown, but its not without interest that nephroprotective mechanisms implicated with GLP-1 RAs in the treatment of T2DM-related kidney disease and tacrolimus-induced nephrotoxicity overlap with pathoetiologic mechanisms implicated with lithium-induced nephrotoxicity
Reduction in glucagon production, 6
Studies show effectiveness for liver health and related metabolic conditions
However, no Phase II or Phase III randomized controlled trials have been published as of 2026, meaning the full safety profile particularly long-term effects, drug interactions, and dose-dependent risks remains incompletely characterized
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