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The joint changes in 3-HB and the C2/C0 ratio accounted for approximately 23% of the weight-lowering treatment effects in participants without T2D

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Rapid weight loss associated with semaglutide may paradoxically increase gallstone formation risk, as noted in FDA prescribing information

The treatment-regimen estimand includes patients who had discontinued the study or required treatment with off-protocol glycemic agents, such as sulfonylureas