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Increases in the percentage of T(/)MCA, (T/G)UDCA, and (T)HDCA were also observed in either the ileum or the feces of MMI + T3-5d mice compared to MMI mice (Fig

doi: 10.1038/s41467-024-51736-5 112 ZhangJDongYYuSHuKZhangLXiongMet al

The authors never discussed the possibility that PGN complexed with the added proteins to effectively reduce the active concentration of the PGN, or the fact that PGN and CGN are two different molecules, by molecular weight and physiochemical properties, and that those properties could have played a role in the differences observed

Basal BRET was measured for 1020 min before adding the agonist or vehicle, after which BRET was continuously measured for an additional 60 min

Some patients find that evening dosing helps manage daytime nausea, whilst others prefer morning administration to monitor symptoms throughout the day

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