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Adults with Obesity: Patients with a body mass index (BMI) of 30 or higher
Most adverse effects associated with GLP-1 agonists are mild to moderate and often improve with time
But effectiveness doesnt always mean safety
In this issue of Diabetologia , Kang et al (DOI: 10.1007/s00125-012-2776-x) provide evidence that in addition to glucotoxicity, lipotoxicity also affects incretin receptor expression and signalling in insulin-secreting cells and isolated islets
However, weight loss medications like GLP-1 injectables are only available with a prescription, following a careful examination by a physician
410 Efforts are underway to develop novel therapies addressing unmet needs, such as alternative agents for long-term management of hyperuricemia
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