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DIRKO) mice, but not in Glp1r / mice (Figure 2)
During these short periods, the liverwhich has a greater capacity for recycling GSH precursors and synthesizing GSH for export to other tissuescan help prevent widespread GSH deficiencies in our body
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meanwhile, IGF-1 overexpression, with adenovirus vector, broke nuclear p53progerin interaction to decrease H 2 O 2 -induced hepatocyte premature senescence
In addition to GLP-1RAs, pioglitazone and SGLT-2 inhibitors are two other classes of diabetic medications that have shown promise in reducing the risk of cardiovascular disease, albeit through different mechanisms
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