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Comparison of pre-workout nitric oxide stimulating dietary supplements on skeletal muscle oxygen saturation, blood nitrate/nitrite, lipid peroxidation, and upper body exercise performance in resistance trained men

doi:10.1177/000348949110000809

In addition, As stimulates the generation of free radicals and reactive oxygen species (ROS), resulting in oxidative stress

Yang JH, Nguyen CD, Lee G, Na C-S (2022) Insamgobonhwan protects neuronal cells from lipid ROS and improves deficient cognitive function

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However, subsequent trials incorporating dietary and exercise interventions produced less conclusive results