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Yang F, Kemp CJ, Henikoff S
Prospective, controlled studies are needed to clarify whether GLP-1RAs have a direct therapeutic role in HS or act primarily through effects on weight and metabolic inflammation
Beyond Month 3: Sustained Loss and Long-Term Success By month 4 and beyond, successful semaglutide patients have typically lost 1015% of their starting weight, with continued loss occurring at a slower, more sustainable pace
The mean (SD) absolute weight loss from the index date to the end of follow-up was 14.6 (9.9) kg in the semaglutide 2.4 mg cohort and 17.2 (11.7) kg in the tirzepatide cohort, which represented a mean (SD) percent weight loss of 14.1% (9.6) and 16.5% (10.8), respectively
Patients should undergo baseline assessments including hemoglobin A1c (for diabetes patients), renal function tests, and lipid panel
Doctors usually begin with a low dose of semaglutide, such as 0.25 mg, given once a week as a subcutaneous injection
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