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[See Dosage and Administration (2.2).] Hepatic Insufficiency In patients with moderate hepatic insufficiency (Child-Pugh score 7 to 9), mean AUC and Cmax of sitagliptin increased approximately 21% and 13%, respectively, compared to healthy matched controls following administration of a single 100 mg dose of Januvia
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Adjusting the dosage or delaying dose escalation often resolves this issue
Korean J Gastroenterol 76(3):150158
Additional compounds worth researching include AOD-9604 , tesofensine , lipo-C peptide , and the emerging GLP-3 peptide
